MakbyAvailable systems
- Epidermal model
- Full-thickness skin
- Fully synthetic matrix skin
- Human iPSC-derived skin organoids
- Disease-specific models
Omnicell / Tissue model specifications
Skin
Investigate formulation performance, drug disposition, pharmacodynamics and skin safety.
01 / Model configurations
Inside the model.
Biological architecture
Epidermal architecture, barrier function and tissue compartments selected for the study.
Endpoints & characterization
- Viability, histopathology and epidermal morphology
- Barrier integrity, TEER and tight-junction proteins
- Inflammatory cytokines
- Deposition in stratum corneum; epidermal, dermal and receptor-fluid concentrations
- Penetration, flux and metabolite formation
- Target engagement, pathway modulation and dose/exposure–response when the target is represented
Testing options
- Skin irritation and corrosion
- Penetration and formulation screening
- Antioxidant and anti-inflammatory effects
- Wound healing, infection and compound testing
- Acute/repeated exposure, cytotoxicity and phototoxicity
Plan your model configuration
Cell sources, donor selection, tissue dimensions, culture duration, exposure schedule and assay acceptance criteria are defined for the selected study. The catalogue does not specify universal values for these parameters.
Model systems and testing options summarized from the September 2026 preclinical NAMs catalogue, page 3. Discuss availability and the endpoints required for your candidate with MAKBY.