MakbyAvailable systems
- Patient-derived hiPSC systems
- Blood–brain barrier (BBB) models
- Disease-specific neurovascular models
- Neuronal platforms with microelectrode array (MEA) readouts
Omnicell / Tissue model specifications
Neurovascular
Link blood–brain barrier transport, brain-side exposure and functional neuronal responses.
01 / Model configurations
Inside the model.
Biological architecture
hiPSC-derived systems for disease-associated genetics, vascular phenotypes and interactions with astrocytes and pericytes.
Endpoints & characterization
- BBB integrity and permeability
- Transporter and efflux activity
- Brain-side concentration and cellular exposure
- Neuronal firing, bursting and synchrony using MEA
- Neurotoxicity and cytotoxicity
- Patient/genotype-specific response
Testing options
- Disease-specific BBB studies, including Alzheimer’s and Parkinson’s contexts
- Bioavailability and CNS candidate assessment
- BBB transport linked to PBPK/IVIVE and human exposure data where available
- Infection studies with human-specific pathogens
Reported characterization
The catalogue reports TEER up to 2,500 Ω·cm², BBB gene expression and tight-junction characterization. These are reported model-characterization results; study-specific performance and experimental conditions should be reviewed with MAKBY.
Plan your model configuration
Cell sources, donor selection, tissue dimensions, culture duration, exposure schedule and assay acceptance criteria are defined for the selected study. The catalogue does not specify universal values for these parameters.
Model systems and testing options summarized from the September 2026 preclinical NAMs catalogue, page 5. Discuss availability and the endpoints required for your candidate with MAKBY.